Landmark Study Finds Mercury Poisoning Causes Autism

Posted on Oct 10, 2008 in Autism, Heavy Metals

For Immediate Release CoMeD President [Rev. Lisa K. Sykes (Richmond, VA) 804-364-8426]
October 10, 2008 CoMeD Sci. Advisor [Dr. King (Lake Hiawatha, NJ) 973-263-4843]

WASHINGTON, DC – New study, “Biomarkers of Environmental Toxicity and Susceptibility in Autism” in
the peer-reviewed Journal of the Neurological Sciences(1), confirms a causal link between subacute mercury
poisoning in children and their autism spectrum disorder (ASD) diagnosis. The autism community reported
that this study presents, “…some compelling evidence…consistent with the author’s theory that mercury
exposure plays a role in autism.”(2)

This paper(3) presents the first prospective, blinded cohort study to examine children diagnosed with an ASD
using: urinary porphyrin profile analysis (UPPA) to assess the body-burden and physiological effects of their
mercury, glutathione analysis to assess susceptibility to mercury poisoning, and Childhood Autism Rating
Scale (CARS) scores to measure ASD severity.

These evaluations(4) established:
• Non-chelated patients diagnosed with an ASD had UPPA profiles indicative of mercury poisoning that
strongly correlated with ASD severity, measured using CARS scores.
• Glutathione (a key biochemical in the body’s mercury detoxification pathway) was significantly lower
in patients diagnosed with an ASD in comparison with its level in neurotypical controls.
• Increasing mercury-poisoning severity, as indicated by the UPPA results, was associated with lower
glutathione levels among the patients diagnosed with an ASD.

Based upon these findings, the researchers concluded, “ASDs may result from a combination of genetic/
biochemical susceptibilities in the form of a reduced ability to excrete mercury and/or increased environ-
mental exposures at key developmental times.”

The Autism Research Institute, the non-profit CoMeD, Inc., and, through a grant from the Brenen Hornstein
Autism Research & Education (BHARE) Foundation, the non-profit Institute of Chronic Illnesses, Inc.
funded this research study.

Today, any parent, physician, or healthcare provider can easily confirm whether or not a non-chelated child
diagnosed with an ASD is mercury poisoned by having UPPA testing run at LabCorp (CLIA-certified, test#
120980) or Laboratoire Philippe Auguste (ISO-certified, 119 Philippe Auguste Avenue, Paris, France
75011). Please, visit CoMeD’s web site, for information on how to order
UPPA tests and full copies of some of the many published papers validating the UPPA test.

Your generous tax-free donations will help us to fund additional research, similar to the present study, to
examine mercury’s links to autism and other illnesses, define the causal roles of mercury in the linked
childhood and adult illnesses, and find appropriate curative therapies.

(1)  Geier DA, Kern JK, Garver CR, Adams JB, Audhya T, Nataf R, Geier MR. Biomarkers of environmental toxicity and
susceptibility in autism. J Neurol Sci. 2008 Sep 24. [Epub ahead of print].
(3)  This new study involved a multi-national collaboration between researchers, including: David A. Geier, Janet K. Kern, PhD, RN,
Carolyn Gavery, PhD, James B. Adams, PhD, Tapan Audhya, PhD, Robert Nataf, MD, and Mark R. Geier, MD, PhD, FABMG,
FACE. These researchers have extensive research backgrounds in medicine, biochemistry and neuroscience, and include
professors from the University of Texas, Southwestern Medical Center (Dallas) and Arizona State University (Tempe).
(4) Laboratoire Philippe Auguste and Vitamin Diagnostics performed biochemical testing; Dr. Kern conducted the CARS scoring.