Posts Tagged ‘diabetes’

90 Percent of Scientists Backing Avandia Diabetes Drug Had Financial Ties to Drug Companies

Wednesday, July 28th, 2010

Friday, July 23, 2010 by: David Gutierrez

More than 90 percent of researchers who have published studies favorable to the controversial diabetes drug Avandia had a financial stake in the issue, according to a study conducted by researchers from the Mayo Clinic.

The Mayo Clinic is one of the few research organizations in the United States that does not accept corporate funding.

Sales of GlaxoSmithKline’s bestselling drug Avandia plunged in 2007, after evidence emerged linking the drug to an increased risk of heart attack and death. These reports sparked a debate over the drug’s safety that continues to this day.

In an analysis of more than 200 studies, articles, editorials and letters published in scientific journals since 2007, Mayo Clinic researchers have concluded that financial conflict of interest continues to play a major role in that debate. Fully 87 percent of all authors who expressed positive views about Avandia had financial ties to GlaxoSmithKline, while another 7 percent had ties to other pharmaceutical companies involved with diabetes. Among authors with financial conflicts of interest, only 30 percent “expressed unfavorable views” of the drug. (more…)

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HEART, VASCULAR, CHOLESTEROL, HIGH BLOOD PRESSURE AND DIABETES—WHAT THEY HAVE IN COMMON

Monday, March 8th, 2010

HEART, VASCULAR, CHOLESTEROL, HIGH BLOOD PRESSURE AND DIABETES—WHAT THEY HAVE IN COMMON 
Terry Chappell, MD 
Celebration of Health Association 
Bluffton, Ohio 
419-358-4627 
www.healthcelebration.com 
 
  The first considerations are diet, exercise and stress control to prevent or treat the various diseases of circulation. Blood pressure is very important, even more so from recent studies. Cholesterol and other lipids are a factor, but only one of many. Half of those who die of heart atttacks have normal cholesterols. If your HDL (the good cholesterol) is low, you really need to exercise. For primary prevention you have to treat 100 people with high cholesterol with a statin drug to prevent one heart atttack. Statins do help some to prevent heart attacks and strokes, but usually red yeast does as well. Either way, it is very important that you take some CoEnzyme Q10, because you lose it when you take these substances and you need it for a healthy heart. 
  Non-insulin dependent diabetes is largely preventable or at least controllable with diet. For most patients, I suggest a restricted carbohydrate diet. Dieticians have been shown to be wrong in the past. Studies show that the a low carbohydrate diet works better than an exchange diet to control diabetes. A raw food diet is difficult, but the results might even be better. There are some excellent herbal and nutrient preparations that can help with BP, lipids, and blood sugar control but nothing that will take the place of diet, exercise and stress control. 
  In my experience, three of the most important factors in preventing circulation problems and heart attacks are preventing abnormal clotting without increasing the risk of hemorrhage, reducing inflammation and removing toxic metals, especially lead and mercury. Intravenous EDTA chelation therapy does all three, I think better and safer than any other treatment program. If clotting is a risk, we often add nattokinase and fish oils. Plavix carries too big a risk of brain hemorrhage for routine use. For inflammation, statin drugs are more dangerous. There is no conclusive evidence that they work any better than fish oils, EDTA, and perhaps some proteolytic enzymes. Nothing is as broad as EDTA for removing toxic metals. The American Heart Association journal has repeatedly demonstrated that even small amounts of lead dramatically increase the risk for heart disease, stroke, cancer, and Alzheimer’s disease. And yet the authors declined to recommend any treatment for it. We treat it early and vigorously because we feel elevated lead is a big factor that deserves attention.

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Why Carbohydrates Are So Important in Diabetes

Wednesday, September 23rd, 2009

Counting carbs at meals and snack time is one method used to control blood sugar.

Carbohydrates are sugar-based molecules found in fruit, vegetables, whole grains, and dairy products. The make up about 45% to 65% of calories in a healthy diet (the exact percentage is hotly debated); the rest come from fat and protein.

You’ll find carbohydrates in the healthiest foods you eat, and in the least healthy. Check the food label to find out exactly how much is in your favorite foods.

How you eat can affect blood sugar
Choosing the right kind of carbohydrates and spacing them out evenly throughout the day can keep blood sugar from rising too high, too fast (90% of the carbohydrate calories you digest end up as glucose, so they have a much bigger impact on blood sugar than fat or protein).

“The goal … is to take in enough carbohydrates to nourish ourselves, but never so much that it causes high blood sugars,” says Linda Sartor, a diabetes nutrition specialist at the Penn Rodebaugh Diabetes Center at the Hospital of the University of Pennsylvania in Philadelphia.

Up until about the mid-1990s experts believed that people with diabetes should never eat foods that contain so-called “simple” sugars-those found in cakes and candy-and instead eat “complex” carbohydrates, or those with longer chains of sugar molecules such as potatoes, fruit, vegetables, and grains. (more…)

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Not Enough Sleep May Increase Risk of Diabetes

Friday, September 18th, 2009

Wednesday, August 12, 2009An inadequate amount of nightly sleep on a recurring basis, coupled with a sedentary lifestyle and overeating, may fuel the development of diabetes, results of a new study hint.

“Our findings suggest that combining the unhealthy aspects of the Westernized lifestyle with insufficient sleep may add to the risk of overweight and sedentary individuals to develop diabetes,” Dr. Plamen Penev, of the University of Chicago, Illinois, and a senior author of the study, told Reuters Health. (more…)

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Medtronic recalls diabetes devices

Friday, July 31st, 2009

Minneapolis / St. Paul Business Journal – by Chris Newmarker Staff Writer

Medtronic Inc. on Friday said it has initiated a recall of infusion sets – thin tubes that deliver insulin from insulin pumps to diabetes patients – because the tubes may not deliver insulin properly.

Fridley-based Medtronic (NYSE:MDT) said the Quick-set infusion sets may not allow insulin pumps to properly vent air pressure, and that could result in diabetics getting too much or too little insulin, a situation that could cause serious injury or death.

About 60,000 of the estimated 3 million infusion sets presently with customers are affected.

The affected infusion sets, sold mostly in the U.S., have reference numbers MMT-396, MMT-397, MMT-398 and MMT-399 with lot numbers starting with the number “8.” Customers with those sets are being told to stop using “Lot 8″ sets. (more…)

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Study Links a Protein with a Diabetes Risk

Wednesday, July 29th, 2009

Connection Seen between Adiponectin and Risk of Developing Type 2 Diabetes
(WebMD) Higher levels of a protein made by fat cells is linked to a lower risk of type 2 diabetes.A new review of research shows people with higher levels of the protein adiponectin consistently have a lower risk of developing type 2 diabetes.

Adiponectin is a protein produced by fat cells that has anti-inflammatory properties. It also makes the body more sensitive to insulin. Reduced insulin sensitivity is a key factor in the development of type 2 diabetes. (more…)

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Cost of Diabetes Totals $218 Billion in U.S. Alone

Sunday, April 19th, 2009

Tuesday, November 18, 2008 | FoxNews.com
As diabetes is rapidly becoming one of the world’s most common diseases, its financial cost is mounting, too, to well over $200 billion a year in the U.S. alone.

A new study, released Tuesday exclusively to The Associated Press, puts the total at $218 billion last year – the first comprehensive estimate of the financial toll diabetes takes, according to Danish pharmaceutical company Novo Nordisk A/S, which paid for the study.

That figure includes direct medical care costs, from insulin and pills for controlling patients’ blood sugar to amputations and hospitalizations, plus indirect costs such as lost productivity, disability and early retirement.

The study, conducted by the Lewin Group consultants, estimates costs to society for people known to have Type 1 or Type 2 diabetes at $174.4 billion combined, a total previously reported by Novo Nordisk, the world’s top producer of insulin and the maker of diabetes pills such as NovoNorm and Prandin. That study was done with the American Diabetes Association.

The new study adds estimates for people who haven’t been diagnosed yet ($18 billion), women who develop diabetes temporarily during pregnancy ($636 million) and those on track to develop diabetes, an increasingly common condition called pre-diabetes ($25 billion).

“Diabetes has not seen a decline or even a plateauing, and the death rate from diabetes continues to rise,” said Dana Haza, senior director of the National Changing Diabetes Program, an effort Novo Nordisk began in 2005 to improve diabetes care and prevention in the U.S.

“The numbers just keep going higher and higher, and what we want to say is, ‘It’s time for government and businesses to focus on it,’” said Haza, who believes diabetes will be the country’s biggest health problem in the future, worsened by the obesity epidemic.

Novo Nordisk is to present the data Tuesday at a health care conference for corporate executives and then plans to publish a full report in a professional journal. The calculations are based on numbers from sources including databases on treatment of people with commercial insurance, Medicare and Medicaid, federal public health surveys and other sources.

Andrew Webber, president and chief executive of the National Business Coalition on Health, said the study is the first he’s seen estimating diabetes costs. He praised its inclusion of indirect costs, which “add up and create such a powerful argument as to why employers need to take this challenge on.”

“This study gives a very persuasive argument to employers to invest in a culture of health in their workforce,” Webber said, calling the worsening diabetes epidemic “the tsunami that is coming.”

Among people known to have diabetes, the new study estimated $10.5 billion in medical costs and $4.4 billion in indirect costs, or a total of $14.9 billion, for people with Type 1 diabetes, which generally begins in youth and can have a genetic link. Nearly 6 percent of the 17.5 million Americans diagnosed with diabetes have Type 1. (more…)

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Diabetes keeps rising among U.S. adults

Wednesday, February 18th, 2009

By Amanda Gardner, HealthDay Reporter
WEDNESDAY, Jan. 28 (HealthDay News) — The most recent analysis of data on diabetes in the United States finds that almost 13 percent of adults aged 20 and older have the condition, 40 percent of whom have not been diagnosed.

That’s a larger proportion of diagnosed patients than noted in a previous study, although the percentage of undiagnosed individuals has remained the same.

“We can say for certain that diagnosed diabetes has increased significantly between the two surveys, from 5.1 percent [in 1988-1994] to 7.7 percent [in 2005-2006]. It seems it has particularly increased in blacks,” said Catherine C. Cowie, director of the Diabetes Epidemiology Program at the U.S. National Institute of Diabetes and Digestive and Kidney Diseases.

“On the other hand, the prevalence of undiagnosed diabetes and pre-diabetes [around 30 percent of the population] is generally stable, and that’s really good news,” she said. “If undiagnosed diabetes has stayed pretty much the same and diagnosed diabetes has gone up, then we’re doing a better job of detecting diabetes.”

Cowie is lead author of a study published in the February issue of Diabetes Care.

The wide prevalence of pre-diabetic conditions is still troubling, experts said. Pre-diabetes is a condition in which blood glucose levels are higher than normal but not high enough to be classified as diabetes. Pre-diabetic people are at increased risk for developing type 2 diabetes, heart disease and stroke.

“There is a large population that has pre-diabetes. Also, one-third are not diagnosed for diabetes and pre-diabetes, so this is a huge population issue that we’ll have to deal with as time goes on,” warned Dr. Spyros Mezitis, an endocrinologist with Lenox Hill and NewYork-Presbyterian hospitals and professor of medicine at Weill Medical College of Cornell University, New York City.

“We’re not working on preventing as much as we should. We have a problem with 20 million Americans having diabetes, but the projections are that this will [dramatically increase],” he said. “We’re not talking about curing the disease in the next few years. It’s all going to be about management.”

Diabetes carries with it a number of serious complications, including kidney failure, blindness, amputation and even death.

The national survey on which this study was based involved almost 7,300 people aged 12 and over who were interviewed in their homes in 2005 and 2006. Participants also had blood glucose measurements taken. This data was compared to earlier data gathered from 1988-1994. (more…)

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Study: Possible diabetes link to arsenic in water

Wednesday, August 20th, 2008

CHICAGO, Illinois (AP) — A new analysis of government data is the first to link low-level arsenic exposure, possibly from drinking water, with type 2 diabetes, researchers say.

The study’s limitations make more research necessary. And public water systems were on their way to meeting tougher U.S. arsenic standards as the data were collected.

Still, the analysis of 788 adults’ medical tests found a nearly fourfold increase in the risk of diabetes in people with low arsenic concentrations in their urine compared with people with even lower levels.

Research outside the United States has linked high levels of arsenic in drinking water with diabetes. It’s the link at low levels that’s new. (more…)

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